Macs use a unix based kernel and filesystem and space out file allocation tables, thus if your hard drive is fragmented, its full and you need a new one.
Alternatively you can use an SSD which performance actually increases with the rate of fragmentation due to the way it accesses data without the use of a drive platter.
CCleaner is great for all platforms.
“A problem can not be solved from the same logical level it was created.”
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I've found there's never a better substitute for fixing performance issues than backing up your personal files & info and then reinstalling OS and programmes...
Be desireless. Be awesome. Be gone
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