Chances are if you are just after her for sex then it won't be too difficult, however if you are after a relationship you may find it a little more difficult. If she has children a similar age to you she will most definitely want to keep your "interaction" discreet depending on her relationship with them.
If it was me I would flirt, get her interested and then make the suggestion that you pop round 1 evening (after the kid who needs full-time care is in bed) with a bottle of wine, maybe some food. If she agrees the writing is on the wall
Either that or grow a mustache like Tom Selleck
Older chicks dig it!